Per tab contains diosmin 450 mg and hesperidia 50 mg: 2 tab/day. Daflon Per tab contains diosmin 450 mg and hesperidia 50 mg: Acute attack: 6 tab/day for 1st 4 days, followed by 4 tab/day for next 3 days; Chronic hemorrhoids: 2 tab/day.
Diosmin and hesperidia are flavonoid compounds. When used together, they prolong the vasoconstrictor effect of noradrenaline on the venous wall, thus increasing venous return and reducing venous hyper pressure present in patients with chronic venous disease. They also improve lymphatic drainage and protect the microcirculation from inflammation. Diosmin and hesperidia are used together in the treatment of venous disease e.g. chronic venous disease and hemorrhoids disease.